Not really - it's just the direction of the thread on the prop bolt. If its a ny-lock type nut it will be fine, if its not a drop of the blue threadlock will stop any untightening.
The confusing thing is that depending on the seller a "CCW" motor can mean CCW threaded for CW rotation, or CW threaded for CCW rotation. As @CarolineTyler stated if you use a nylock nut it won't really matter.