Yes, I fly away everyday on a Mac with AeroFly 5.7. Have a 27" iMac and made mistake when I purchased and did not go for the better graphics setup. Have the AMD Radeon HD 6770M 512 MB. It runs it ok but have to turn a few things down for the 4D locations. No problem with the picture background. Aerofly Profession Deluxe, or AFPD, only has 3d and works great. Started with AFPD and upgraded to 5.7. the upgrade was worth it. Really enjoy the sim.
When I fly and have a problem, I can use 5.7 to set up the same conditions and find what I did wrong and practice to avoid the problem outside.
As for radio, use Spektrum DX6i. Get the adapter cable from Aerofly.
My box came without the adapter cable and USB device. Phone call and they sent one. Said that had never happened before, so sure you will not have that issue. grin