Need to know if I can run it off of 4s.
I agree with Litterbug, with motors, any voltage will work just as long as you don't over prop it. The higher the voltage the smaller the prop will need to be. I like to run a prop test on any new setup.
I think I would start with a 6 or 7 inch prop on 4S. Run the motor full throttle for 10 seconds, then stop, check the temperatures of the motor, esc & battery by touching them. Warm is OK, but if so hot you don't want to hold them, then stop. Try a smaller prop. If it passes, try a 30 second run. If it passes, try a 60 second run. If it passes, it's time for a fly. It always a good practice to check the temp of everything when you land. Stuff that worked when it mild outside, may over heat when it's hot outside.