I'm not sure if I understand your question. If you are making a small cardboard prototype of a plane, I'd say yes, try it in foam board. Using cardboard for a small model (10"-15" wing) is not going to be a fair test. The wing loading will be too heavy. If you made a normal size plane (35"-50" wing) I'd say no, probably not going to work in foam board.
I have found in my normal size planes a wing loading of 10-15 oz/sqft works well. But in a small indoor plane wing loading needs to be 1-2 oz/sqft. A 10X difference.
I have a buddy who always makes a paper prototype of his planes. He does this to find his ideal CG.