I wouldn't risk burning out the motor with the 6x4. You can always under prop an electric motor, but never over prop.
You should only need a 1:1 power ratio. So the thrust from both motors added together should equal about the weight of the entire plane. You probably want the thrust to be more than the weight of the plane, but you don't need crazy unlimited vertical on it. Unless that's what you're after.
When looking for a battery, watch out for the C rating. You have to remember that the battery is going to be supplying two motors. So if each motor takes 20 amps, then you need a battery that can supply at least 40 amps. Same with the ESC if you're only using one. But if you want differential thrust, then you want two ESCs but only use the red wire on one of them. Two red wires means they will both be powering the Rx which will be twice the power it needs and it will burn out the Rx.