Well, bigger flies better alright, but a 400 doesn't really fit that bill. A 500 600 or 700 would be more stable. I've been told again and again by pretty advanced pilots that if you can fly a 450 then you can fly anything. That's because they are so twitchy and fast. Anything but stable. If you are just starting or getting back into it after a long time, I would stay away from the 400's because of the cost involved. Every crash is 50 bucks. Spend some money on a good simulator (I highly recommend Phoenix) and it will pay for itself ten fold. If you are relearning, that might do it. If you are learning for the first time, I would say go with something like and MSR or SR, something designed to be more tame. If you can hover a CP+, then the SR would probably be the way to go. The great thing about the MSR though, is how tough and durable they are. I crashed countless times and never broke anything. It wasn't until I started flying at full speed doing figure eights around the gym that I started crashing really hard and it still took a lot before anything broke.
It's really up to you, your skill, your comfort level, your pocket book. Before jumping any one direction I would do a lot of research and ask a lot of questions. The videos on Horizonhobby.com are really good. Every heli has a video and they tell you who they are geared for. I keep talking about the Blade line only because that's what I'm familiar with and they are really geared towards new pilots as well as advanced.