depends on the FC -> ESC protocol, some of the current 'quad' setups use bi-directional data between the ESC and FC, so you can't run multiple ESCs on a channel. But if you use a singular direction protocol, then you can have multiple ESCs running on a single channel.
now, is it a good idea? probably not, having individual control over each motor will allow the FC to have more control over the over all flying characteristics of the craft.
Also, for more then 4 motors, they are typically arranged as points on a n-gon with the angles and sides all the same length, with alternating CW/CCW rotation of the motors.