This has been a question I've often pondered over for a conisderable amount of time, I am also currently in the process of drawing up plans for a scratch build, (will be making a forum post on that shortly) but for this one I'm using the software autodesk fusion. I'm attempting to make "sketches" of all the ribs, which I well then be able to export as a DXF format. This format can be converted to png, pdf, or even sent to a laser cutter.
(I'm not sure if you're familiar with the software, but in autodesk fusion 360 a sketch is what they define as a 2D drawing confined to a single workplane. Working with multiple planes you can create several sketches at different angles to build up 3D profiles.)
I will admit this probably works best for the style of build I'm going for, being a sheet-depron covered, ribbed structure, similar to a balsa build. However, it still stands that the measurement tools in this software are great, and the ability to export sketches into essentiallly any format is increadibly useful.
So for attempting something perhaps along the style of a flite test build one could certainly create sketches of all the panels required, in 3D, then either redraw, or move/rotate the sketches to their respective positions required for a 2 dimensional format. I would personally guess it is best to redraw multiple sketches into one single 2D sketch using measurements you obtain then from the 3D versions into a 2D plan.
Another tool which I cannot say I have tried for building planes myself but know exists and have played around with for other tasks is pepakura. This would probably be what one could consider a foam plane builders' dream tool, as it does all of the hard work for you. It can take any 3D model, literally unfold it, and turn it into a set of 2D plans. However, this tool was designed for paper, hence the name, and not for foamboard. So in generating a paper template, it adds a load of tabs for gluing, which you would obviously omit, but also comes up with sometimes some rather odd geometry. But as it's obviously assuming it's working with paper and not foamboard, there are several foamboard building techniques that it will not try to emulate. It also means you will probably end up with a thicker model than you bargained for if you follow the plans strictly. So, if you're thinking of using pepakura, I'd reckon you'll be needing to modify the paper template it outputs heavily, before it can be anything feasably usable.
Hope this information is helpful.