1C = 2.2A on a 2200mAh battery.
4 x 15A = 60A
60A / 2.2A = 27C
If your power setup pulls the 15 amp rating per ESC, you'd want at least a 30C battery to provide enough current. But since you rarely, and only briefly when you do, run wide open throttle on a multicopter you don't need to worry about the high end of the limits. Not to mention your ESCs should be rated for 120% of your motor/prop combination will ask for.
Short story is that any 25C battery will do fine for your Knuckle build.