By trim, I assume you mean some preset on the control surfaces of the plane. I don't have a D6 G2 but the principles are pretty universal. I took a look at the DX G2 manual since different terms are used to mean the same thing.
There are three ways to "trim"
1. Physically on the plane - Adjust the control rod length to set the "center" of control surface. Adjust the length of the control horn on the servo and/or the control surface to change how far the control surface moves - the throws. You have to do this if you build a plane. You may need to do this if you have to repair a plane and you might need to make some adjustments to a new pre-made plane out of the box, particularly if it needs assembly.
2. The servo configuration on the TX - You can adjust the servo center (aka sub trim) and max servo throws (aka travel adjust) and servo direction (aka reverse) for each channel electronically on programmable Transmitters. Generally it is easier to make final fine adjustment electronically. If you find you need to make big adjustments, this can work as a temporary fix but it's better to fix the plane..see 1.
Assuming you have a Dx6 G2 see page 28 of this manual for how to change the values
https://www.horizonhobby.com/pdf/SPM6700-Manual_EN.pdf .
I don't see why SAFE should prevent you from making adjustments here but I suspect they would be subtle on a plane set up for that.
3. When flying - there are trim buttons next to the sticks that by default will offset the value the stick sends essentially allowing you to set the what center means for the control surface. It adds an extra offset to the sub-trim you configured. Roughly you want level straight flight with centered sticks - throttle may vary. The DX6 has a bunch of modes for these trim buttons - page 17 - but to start you just want "Common"